Medical journal studies case of Reglan-induced depression, suicide
There was nothing in their 47 years of marriage that would make Lucy* suspect her husband Joe* was anything besides energetic and optimistic. That all changed when the 70-year-old was prescribed the drug Reglan, also known by the generic metoclopramide, to treat a sliding hiatal hernia with moderate gastroesophageal reflux. Just three months after starting Reglan, Joe began to complain that he was depressed. His depression continued to worsen, and three months later he was prescribed Zoloft. When Zoloft did nothing to improve his spirits, Joe tried three other antidepressants, Prozac, Effexor and Celexa. Nothing seemed to help.

