Reglan Side Effects
Reglan (metoclopramide) works by speeding up the movement of the stomach muscles, thus increasing the rate at which the stomach empties into the intestines. It is used as a treatment for gastroesophageal reflux disease in patients who have not responded to other therapies, and to treat diabetic gastroparesis.
Chronic use of Reglan (metoclopramide) has been linked to tardive dyskinesia, which may include involuntary and repetitive movements of the body, even after the drugs are no longer taken. FDA officials are warning health care providers against chronic use of Reglan (metoclopramide) therapy in all but rare cases where the benefit is believed to outweigh the risk.
Manufacturers will be required to implement a risk evaluation and mitigation strategy, or REMS, to ensure patients are provided with a mediation guide that discusses the risk.
Common Reglan side effects include:
- decreased energy
- trouble sleeping
Severe Reglan side effects may include:
- Tardive dyskinesia – involuntary, repetitive movements of the extremities, or lip smacking, grimacing, tongue protrusion, rapid eye movements or blinking, puckering and pursing of the lips, or impaired movement of the fingers.
- Severe allergic reaction – rash, hives, itching, difficulty breathing, tightness in the chest, swelling of the mouth, face, lips or tongue; unusual hoarseness
- Abnormal thinking, confusion
- Mental or mood changes – depression, anxiety, agitation, jitteriness
- Suicidal thoughts or actions
- Decreased coordination
- Fast, slow or irregular heartbeat
- Severe or persistent dizziness, headache or trouble sleeping
- Severe or persistent restlessness, including inability to sit still
- Stiff or rigid muscles
- Loss of bladder control
- Swelling of the arms, legs or feet
Symptoms of tardive dyskinesia are rarely reversible and there is no known treatment.