Tardive Dyskinesia has been linked to types of antidepressants such as SSRIs (selective serotonin reuptake inhibitors) and SSNRs (serotonin-norepineprine reuptake inhibitors). It also was recently linked to gastrophageal reflux medication Reglan. Tardive Dyskinesia is often irreversible even after the drug has been discontinued.

PMDD, a condition associated with severe emotional and physical problems linked closely to the menstrual cycle, affects about 5 percent of menstruating women. Both PMDD and PMS share common symptoms such as depression, anxiety, tension, irritability and moodiness, however PMDD is far more severe. It is often treated with antidepressants and anti-anxiety drugs, such as those classified as SSRIs and SSNRs.

Sarafem is believed to correct the imbalance of serotonin that may contribute to PMDD. Although Sarafem is not a treatment for depression, it contains fluoxetine hydrochloride, the same active ingredient in some antidepressants. Like other SSRIs and SSNRs, Sarafem also carries a warning of suicidal thoughts and behavior.

Patients are advised to discuss with their doctor any side effects experienced while taking Sarafem. Negative side effects should be reported to the Food and Drug Administration (FDA) online at www.fda.gov/medwatch, or by phone at 1-800-FDA-1088.

SOURCE: Reglan Side Effects › PMDD medication linked to Tardive Dyskinesia